This paper deals with the performance enhancement for crystallization unit of a sugar plant using genetic algorithm. The crystallization unit of a sugar industry has three main subsystems arranged in series. Considering exponential distribution for the probable failures and repairs, the mathematical formulation of the problem is done using probabilistic approach, and different...

Crystallization of active pharmaceutical ingredient (API) or pharmaceutical drug substances is a crucial unit operation. In this paper challenges and scientific progress over the last two decades in the areas of pharmaceutical crystallization thermodynamics, kinetics, polymorphism, process modeling, and process control were attempted. Effective utilization of such scientific knowledge for optim...

Crystallization from solution is an industrially important unit operation due to its ability to provide high purity separations. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview on recent developments in t...

This study reassesses the development of compositional layering during the growth of granitic plutons, with emphasis on fractional crystallization and its interaction with both injection and inflationrelated deformation. The Dolbel batholith (SW Niger) consists of 14, kilometre-sized plutons emplaced by pulsed magma inputs. Each pluton has a coarse-grained core and a peripheral layered series. ...

The collapse temperature (Tc) and the glass transition temperature of freeze-concentrated solutions (Tg') as well as the crystallization behavior of excipients are important physicochemical characteristics which guide the cycle development in freeze-drying. The most frequently used methods to determine these values are differential scanning calorimetry (DSC) and freeze-drying microscopy (FDM). ...

We studied nucleation and crystal growth in two polypropylene samples by analyzing the number of spherulites, their size, and shape for various treatments in a hot-stage microscope. The consistency of nucleation and growth data were tested by using overall crystallization experiments and the Jonhson–Mehl–Avrami–Kolmogorov Q1 equation. In isothermal conditions, for temperatures, TC, varying betw...

All bent out of shape: The solvent of crystallization effectively enhances the emission of flexible, bent, π-conjugated molecules in the crystalline state owing to control of the packing of the molecules in the structure. Multichromism such as thermochromism and vapochromism also arises from the solvent-controlled packing. This crystalline-state emission is attributable to the flexibility of cy...

The crystallization of proteins is dependent on the careful control of numerous parameters, one of these being pH. The pH of crystallization is generally reported as that of the buffer; however, the true pH has been found to be as many as four pH units away. Measurement of pH with a meter is time-consuming and requires the reformatting of the crystallization solution. To overcome this, a high-t...

Two-dimensional (2D) crystallization on solid surfaces is governed by a subtle balance of supramolecular and interfacial interactions. However, these subtle interactions often make the prediction of supramolecular structure from the molecular structure impossible. As a consequence, surface-based 2D crystallization has often been studied on a case-by-case basis, which hinders the identification ...